Choliva 10mg Tablet | Farnesoid X-receptor agonist | ePharma
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Choliva 10mg Tablet

Generic: Obeticholic Acid

Type: Tablet

Pack Size: 10pcs

Choliva 10mg Tablet is used alone or in combination with treatment for certain liver diseases (primary biliary cholangitis-PBC).


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Discount Price: ৳ 528
MRP: ৳ 550 4% Off

⪼ Save  ৳: 22  in this Product


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✅ Description:

Biliary cirrhosis, also known as primary biliary cholangitis (PBC), is indeed an autoimmune disease that primarily affects the liver and bile ducts. The gradual destruction of the small bile ducts in the liver leads to the accumulation of bile and toxins, causing liver scarring and, eventually, cirrhosis.

The symptoms of PBC can be subtle or absent in the early stages, making it challenging to diagnose. Common early symptoms, as you mentioned, include itching (pruritus), fatigue, and dryness of the mouth and eyes. As the disease progresses, more noticeable symptoms may develop, such as pain in the upper right abdomen, swelling of the spleen, and jaundice.

The exact cause of PBC remains unclear, but it is believed to involve an autoimmune response, as you described, with T lymphocytes mistakenly attacking and damaging the healthy bile duct cells.

While there is no permanent cure for PBC, various treatment options are available to manage symptoms, slow down the progression of bile duct damage, and improve liver function. Medications like ursodeoxycholic acid (UDCA) and obeticholic acid are commonly used to treat the condition. In some cases, liver transplantation may be necessary for those with advanced liver disease.

Safety Advices


Alcohol
UNSAFE

It is not known if alcohol interacts with Choliva 10mg Tablet. Consult your doctor if you have any concerns.


Pregnancy
UNSAFE

Please consult your doctor if you are pregnant, as limited information is available regarding the usage of Choliva 10mg Tablet during pregnancy.


Breastfeeding
CONSULT YOUR DOCTOR

Consult your doctor if you are breastfeeding; your doctor will decide whether Choliva 10mg Tablet can be taken by breastfeeding mothers or not.


Driving
CAUTION

Choliva 10mg Tablet does not affect your ability to drive. However, you are advised to omit driving if you experience dizziness.


Kidney
CONSULT YOUR DOCTOR

Please consult your doctor if you have kidney impairment or any concerns regarding this.


Liver
CONSULT YOUR DOCTOR

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this. Inform your doctor if you have/had liver cirrhosis.

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✔️ Uses

Primary biliary cirrhosis

✔️ Side Effects of Choliva 10mg Tablet
  • Mouth or throat pain
  • Fast, irregular, or pounding heartbeat
  • Rash
  • Dizziness
  • Fainting
  • Swelling of the hands, feet, ankles, or lower legs
  • Joint or muscle pain
  • Constipation
✔️ Quick Suggestions:

Maintaining a healthy lifestyle is crucial for individuals with Primary Biliary Cholangitis (PBC) to improve their well-being and manage or prevent certain associated symptoms. Upon diagnosis, your doctor might recommend the following:

  1. Adopt a low-sodium diet if you experience fluid retention (edema or ascites).
  2. Reduce fat consumption if you are overweight or have fatty liver.
  3. Stay well-hydrated by drinking plenty of water.
  4. Limit or avoid alcohol intake.
  5. Minimize stress when possible.
  6. Incorporate exercise into your routine, such as walking.
  7. Quit smoking.
  8. Implement a proper skincare regimen.
  9. Schedule regular dental check-ups.
✔️ Indication

Obeticholic acid is indicated for primary biliary cholangitis (PBC). It can be used in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA for at least 1 year. It can also be used as monotherapy in adults who are unable to tolerate UDCA.

✔️ Pharmacology

Obeticholic acid is an agonist of the farnesoid X receptor (FXR), a nuclear receptor found in the liver, intestine, kidney, and adipose tissue. FXR regulates various target genes involved in controlling bile acid synthesis and transport, lipid metabolism, and glucose homeostasis. FXR activation reduces de novo synthesis of bile acids in hepatocytes and increases the transport of bile acids out of hepatocytes, thereby reducing hepatocyte exposure to bile acid.

✔️ Dosage & Administration of Choliva 10mg Tablet

Adult Dose
For noncirrhotic or compensated Child-Pugh class A patients:

  • Starting dose: 5 mg orally once daily
  • Dosage titration: If an adequate response has not been achieved after 3 months at 5 mg/day, and obeticholic acid is being tolerated, increase the dose to 10 mg once daily. The maximum dosage is 10 mg/day.

For Child-Pugh class B or C patients, or those with a prior decompensation event:

  • Starting dose: 5 mg orally once weekly
  • Dosage titration: If an adequate response has not been achieved after 3 months at 5 mg once weekly, and obeticholic acid is being tolerated, increase the dose to 5 mg twice weekly (at least 3 days apart). The dosage may be titrated to 10 mg twice weekly (at least 3 days apart) based on response and tolerability.

Obeticholic acid may be taken with or without food. If taken concomitantly with a bile-acid binding resin, it should be separated by at least 4 hours.

✔️ Interaction
  • Bile-acid binding resins may reduce the absorption, systemic exposure, and efficacy of obeticholic acid.
  • Coadministration of warfarin and obeticholic acid has been shown to decrease the INR; monitor the INR and adjust the warfarin dose accordingly.
  • Coadministration with CYP1A2 substrates (e.g., theophylline, tizanidine) may increase exposure to CYP1A2 substrates, so monitor these substrates with a narrow therapeutic index.
  • Avoid concomitant use of inhibitors of the bile salt efflux pump (BSEP) (e.g., cyclosporine); BSEP inhibitors may exacerbate the accumulation of conjugated bile salts in the liver and result in clinical symptoms.
✔️ Contraindications

Obeticholic acid is contraindicated in cases of complete biliary obstruction.

✔️ Pregnancy & Lactation

The little human data on Obeticholic Acid consumption during pregnancy is insufficient to establish a drug-associated danger. There is no information on Obeticholic Acid's presence in human milk, its effects on breast-fed infants, or its impact on milk production.

✔️ Precaution & Warnings:
  • Hepatic decompensation and failure, in some cases fatal, have been reported, particularly in patients with decompensated cirrhosis or Child-Pugh Class B or C hepatic impairment when obeticholic acid was dosed more frequently than the recommended starting dosage of 5 mg once weekly.
  • Patients should be monitored for liver enzyme elevations and risks of hepatic decompensation.
  • A dose-response relationship has been observed for liver-related adverse reactions, including jaundice, worsening ascites, and primary biliary cholangitis flare at doses exceeding 10 mg/day.
  • The effect of obeticholic acid on lactation is unknown, and it is unclear if it is distributed in human breast milk.
  • Consider the benefits of breastfeeding and the mother's clinical need for the drug along with any potential adverse effects on the breastfed infant.
✔️ Storage Conditions

Keep at 15°C to 30°C in a dry, light-protected location. Keep out of children's reach.

Frequently Asked Questions (FAQ)

Individuals experiencing symptoms such as excessive itching, fatigue, dry mouth, and dry eyes may need diagnostic tests. These tests include blood tests to assess cholesterol levels, liver enzyme levels, and specific antibodies. A positive diagnosis makes the person eligible for treatment.

Choliva 10mg Tablet, alone or combined with ursodiol, is used to treat primary biliary cholangitis (PBC), a liver disease that damages bile ducts, leading to bile accumulation and liver damage. It falls under the category of farnesoid X receptor agonists, functioning by reducing liver bile production and enhancing bile removal. This treatment is suitable for individuals who cannot take ursodiol or didn't respond well to it as a standalone therapy.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Choliva 10mg Tablet helps improve liver functioning by reducing the production and build-up of bile in the liver and reduces inflammation.

Primary Biliary Cholangitis (PBC) predominantly affects women, who are nine times more likely to develop the condition, constituting approximately 90% of PBC cases. This liver disease typically manifests during middle age and is commonly diagnosed in individuals aged 35 to 60 years. PBC seems to have a genetic predisposition, often clustering within families and appearing more frequently in siblings or among relatives of affected individuals.
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Check our pricing section for Choliva 10mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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